Structural studies of chromatin – University of Copenhagen

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Structural studies of chromatin regulating complexes formed by histone demethylases from the KDM5B family and their interaction partners

The aims of the project are to characterize multi-protein complexes of putative cancer target KDM5B with its interaction partners, particularly components of Z3 co-regulator complex (namely ZMYND8, ZNF592 and ZNF687). This will contribute to the understanding of the role of these protein complexes in transcriptional regulation and will test the broader hypothesis that the chromatin methylation machinery drives chromatin looping in eukaryotic cells.

Participants:
Associate professor Bente Vestergaard (ILF, SUND)
Professor Kell Mortensen, Niels Bohr Institute, SCIENCE
Associate professor Kasper Dyrberg Rand, IF, SUND
Professor Michael Gajede, IFL, SUND