Conformational stages of full-length membrane-bound receptors and transporters – University of Copenhagen

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Conformational stages of full-length membrane-bound receptors and transporters

The overall aim is to determine low resolution structures of membrane-bound receptors and trasnporters as well as ligand-induced structural rearrangements by using combined synchrotron small angle x-ray scattering (SAXS) and small angle neutron scattering (SANS). This will lead to increased knowledge of theses systems as drug targets, specifically laeding to the identification and understanding of new sites for interactions with ligands for modulation of function. This research will be at the forefront of structural biology and will require method developements and extensive use of international synchrotron X-ray and neutron scattering facilities.

This project is realized throuch a collaboration between researchers from Department of Drug Design and Pharmacology, Faculty of Healt and Medical Sciences and the Niels Bohr Institute, Faculty of Science.

Participants:
Associate professor Osman Mirza, Department of Drug Design and Pharmacology
Associate professor Jette Sandholm Kastrup, Department of Drug Design and Pharmacology
Associate professor Lise Arleth, Niels Bohr Institute

Post doc Nis Pedersen, funded by CoNeXT (November 2013 - April 2014)
NN Post doc (September 2014 - August 2016)
NN PhD student (August 2014 - August 2017)

Post doc Heidi Asschenfeldt Ernst
Post doc Søren Roi Midtgaard
PhD student Bala Krishna
Technician Sussi Rosenørn Dohn