Paragraph method development – University of Copenhagen

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Paragraph method development

A variety of projects within CoNeXT concerns the development of new basic instrumentation for X-ray and neutron scattering, new auxiliary equipment and new advanced methods for data treatment that ensure an optimal outcome of these techniques.

The use of advanced neutron optics has evolved over the last decade with the advent of well-defined mirrors, innovative ideas and stronger simulation tools. The CoNeXT project was inspired by the SELENE-guide concept to use McStas-simulations to evaluate the appliation of "Montel geometry" to define the neutron beam spot on the sample, with BIFROST used as the test case. The project resulted in an improved description of mirror waviness in McStas and show that an 8 meter Montel optics section will work very well for neutron wavelengths above 2 and sample sizes in the range 0.1 mm to 3 mm. It is possible to tailor the beam to size and shape by inserting a sample-shaped diaphragm before the Montel optics section.

For X-ray imaging, a CoNeXT project has developed new algorithm showing that 3D-virtual histology Synchrotron radiation μCT tomography evaluations has an inherent statistical uncertainty that is only half of that observed in 2D virtual histology. Thereby the porject has added important new knowledge by describing the geometry and distribution of bone in osseo-integration of titanium implants. The results have emphasixed that the SRμCT method in bone and implant evaluation is todays golden standard for obtaining high resolution, artifact-free, very exact, vast amounts of tomographic images in 3 dimensions. The interdisciplinary collaboration lines bone-biology and physics.

The CoNeXT development on new axillary instrumentation includes micro-fluids systems. Our aim has been to make in-situ time-resolved X-ray studies possible. We have developed a relative simple system based on a thiolene-polymer system with polystyrene X-ray windows. The microfluidic system acts as a diffusive mixer based on hydrodynamic focusing. This thiolene-based chip is easy and fast to manufacture and efficient on the synchrotron beamline.

A CoNeXT project aimed for pharmaceutical materials research combine techniques that are known in physics and chemical crystallography, but that are unknown in the study of pharmaceutical materials. Such new tools aim for more realistic systems that are close to the pharmaceutical production line. The methods include inelastic X-ray and neutron scattering techniques that combined with theoretical calculations have proven their ability to provide important information on the dynamics of molecular crystalline sytems of pharmaceutical relevance.

Kim Lefmann
Anders Østergaard Madsen
Brian Vinter
Kell Mortensen
Robert Feidenhans'l